Page 171 - Livre électronique du Congrès National de Pneumologie 2018

P91 THE EFFECTS OF OBESITY AND TOBACCO USE ON PULMONARY FUNCTION

F. Guezguez, A. Sayhi, I. Anana, I. Ghannouchi, H. Ben Saad, S. Rouatbi

DEPARTMENT OF PHYSIOLOGY AND FUNCTIONAL EXPLORATIONS, UNIVERSITY HOSPITAL OF FARHAT HACHED, SOUSSE, TUNISIA

Introduction : The obesity epidemic has now overlapped the tobacco epidemic for several decades, and the interplay
of these two highly prevalent and known risk factors for impairment of pulmonary function needs to be better
understood.

Aim : to assess the effect of obesity and tobacco use on pulmonary function.
Methods : This is a cross-sectional analysis study, which was conducted in the department of Physiology and
Functional Explorations (University Hospital of Farhat Hached) Sousse, Tunisia. Fourty eight obese subjects (BMI>30
kg/m-2) were included and devided in two groups according to smoking status: group A (GA:22 never smokers) and
group B (GB:26 heavy smokers). Demographic, anthropometric and clinical data were retrieved. Pulmonary function
testing including plethysmography and diffusing capacity measurements were underwent. Data entry and analysis
were performed using STATISTICA software. Statistical comparisons between the groups were performed using Mann
Whitney U-test. A p value 0.05 was considered statistically significant.

Results : The two groups were comparable for age (GA: 48.07±8.29 years, GB: 45.63±11.24 years) gender and
anthropometric data. No difference was found between the two groups for pulmonary flow rates (GA: FEV1= 91.69 ±
17.64%, FEF25-75= 84.53 ± 24.62%; GB: FEV1=90.5 ± 13.86%, FEF25-75=84.68 ± 22.28%), as well as pulmonary
volumes (GA: TLC=87.61±15.31% and FVC=93.38±17.82%; GB: TLC=85.86±14.41% and FVC=90.63±14.54)
expressed as a percentage of the predicted. The same is true for the diffusion capacity (GA: DLCO= 103.11±23.39;
GB: DLCO=103.09±23.62%), p>0.05.

Conclusion : Surprisingly, lung volumes, flow rates and diffusing capacity did not seem to be affected by smoking in
case of obesity. Indeed, obesity could mask the effect of tobacco use on pulmonary function by decreasing the oxidant
stress induced by tobacco smoke.

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